Anionic Amphiphilic Dendrimers as Antibacterial Agents

Dendrimers as Antibacterial Agents

Water-stable ammonium-terminated carbosilane dendrimers as efficient antibacterial agents.

A new family of amine- and ammonium-terminated carbosilane dendrimers of the type Gn-[Si(CH2)3N(Et)CH2CH2NMe2]x and Gn-{[Si(CH2)(3)N+R(Et)CH2CH2N+RMe2]x(X-)y} (where n = 1, 2 and 3; R = H, X = Cl; R = Me, X = I) respectively has been synthesized by hydrosilylation of N,N-dimethyl-N'-allyl-N'-ethyl-ethylenediamine, [(CH2=CH-CH2)(Et)N(CH2)2NMe2] with the corresponding hydride-terminated dendrimer...

Pyridinium based amphiphilic hydrogelators as potential antibacterial agents

The numerous applications of hydrogelators have led to rapid expansion of this field. In the present work we report the facile synthesis of amphiphilic hydrogelators having a quaternary pyridinium unit coupled to a hydrophobic long alkyl chain through an amide bond. Different amphiphiles with various hydrophobic chain length and polar head groups were rationally designed and synthesized to deve...

Dendrimers as anti-inflammatory agents

Pramod Avti is a Postdoctoral Fellow at Montreal Heart Institute, Montreal, Q u e b e c , C a n a d a w o r k i n g o n a collaborative project with Department of Chemistry, McGill University and Ecole Polytechnique, Montreal Canada. His current scientific interests include multifunctional nanomaterials synthesis, and their biomedical applications. In particular, his research is aimed at synthe...

Adsorption characteristics of amphiphilic dendrimers

With the aid of Monte Carlo simulations we investigate the equilibrium behavior of amphiphilic dendrimers, isolated as well as in the vicinity of uncharged planar walls, whereby the coreand shell-monomers constituting the dendrimer interact differently among themselves and with the wall surface. Contrary to the dense-core-forming athermal dendrimers, amphiphilic dendrimers can exhibit the so-ca...